The Mayo Lab’s Family Story

Episode Guests:

Caroline & Cal Mayo

The first full episode of Season 2 of The Mayo Lab podcast began with Caroline and Cal Mayo joining co-hosts Meagen Rosenthal, Ph.D, and Alexis Lee to talk about how the Thomas Hayes Mayo Lab was established, the memory of their son Thomas and the stigma surrounding mental health and substance use issues.

Cal and Caroline shared the story of Thomas, who struggled with drug use while attending the University of Mississippi and passed away from an accidental overdose caused by Fentanyl in 2022. Through a heartfelt and honest conversation, the Mayos open up about their personal journeys as parents and what advice they give to families dealing with similar challenges.


As a parent, you have to keep your tentacles out there as best you can, keep the antenna up to see things and hear things, but getting the information, be willing to make mistakes with your children. Don’t give up, and don’t feel like you have to have all the answers as parents, because we don’t.

— Cal Mayo


In a discussion that dissected stigma, Cal said, “I tell this to groups I talk to. None of us are wired perfectly. We all have our anxieties, depressions, emotional distress moments that will come up in our lives. It is hard for us to admit that, because we want people to think that we not necessarily are perfect, but that we don’t have problems. And we do.”

For parents whose child is struggling with mental health or substance misuse right now, Caroline believes in framing conversations as an opportunity for parents to listen and support. “Let them know that you’re not going to judge,” she said. “We told Thomas often, ‘We’re on Team Thomas. We’re on your team.’ Just let your family members know that.”

Cal and Caroline offered takeaways for changing conversations, underscoring the importance of taking action now. Engaging in vital discussions this year is particularly important, according to Cal.

“It’s an election year in Mississippi, right? What better time to be having conversations about mental health with our state leaders?” asked Cal. “Let’s make sure that the people we elect are committed to really addressing the issue and putting whatever resources we can…We can eventually get there, but this is a perfect time to have those conversations going into the fall before the elections in November.”

Cal and Caroline Mayo are important reminders that compassionate dialogue, honesty and support can help fight the stigma that surrounds metal health and substance misuse. To hear more from Episode 1 of Season 2, scroll down to listen to the first episode or read the transcript.

Watch the podcast on YouTube:

Previous
Previous

The Words We Use Matter

Next
Next

An Introduction to Stigma